Junctional Adhesion Molecule-Like Protein (JAML) Is Correlated with Prognosis and Immune Infiltrates in Lung Adenocarcinoma

16 January 2022: Database Analysis

Likui Fang ^ABCDEF , Wenfeng Yu ^BCD , Guocan Yu ^CDF , Fangming Zhong ^DF , Bo Ye ^ABCDEF*

DOI: 10.12659/MSM.933503

Med Sci Monit 2022; 28:e933503

Table 3 Correlation analysis between JAML and markers of immune cells in GEPIA.

Cell type	Gene marker	Normal		Tumor
Cell type	Gene marker	R	P	R	P
B cell	CD19	0.051	0.7	0.26	5.1e–09
B cell	CD79A	0.034	0.8	0.17	0.00019
CD8+ T cell	CD8A	0.0034	0.98	0.26	4.4e–09
CD8+ T cell	CD8B	0.046	0.73	0.14	0.0022
Tfh	BCL6	−7e-04	1	0.11	0.019
Tfh	IL21	−0.049	0.71	0.24	9.5e-08
Th1	TBX21	−0.096	0.47	0.095	0.036
	STAT4	−0.023	0.86	0.27	8.2e-10
	STAT1	−0.02	0.88	0.14	0.0016
	IFNG	−0.011	0.94	0.19	4.2e-05
	TNF	0.15	0.26	0.37	0
Th2	GATA3	−0.077	0.56	−0.0012	0.98
	IL13	−0.1	0.44	0.19	1.7e-05
	STAT6	0.11	0.41	0.31	3.8e-12
	STAT5A	0.5	5.5e-05	0.62	0
Th17	STAT3	−0.0029	0.98	0.078	0.085
Th17	IL17A	0.079	0.55	0.12	0.0085
Treg	FOXP3	0.11	0.42	0.47	0
	STAT5B	−0.077	0.56	0.36	2.2e-16
	CCR8	0.14	0.3	0.48	0
	TGFB1	0.51	3.8e-05	0.35	3.1e-15
M1	NOS2	−0.24	0.065	−0.022	0.63
	IRF5	0.79	1e-13	0.42	0
	PTGS2	−0.086	0.52	−0.14	0.0029
M2	CD163	0.29	0.027	0.39	0
	VSIG4	0.68	4.3e-09	0.64	0
	MS4A4A	0.7	5.1e-10	0.6	0
TAM	CCL2	−0.039	0.77	0.2	7.4e-06
	CD68	0.66	1.2e-08	0.61	0
	IL10	−0.044	0.74	0.4	0
Monocyte	CD86	0.45	0.00037	0.64	0
Monocyte	CD115	0.49	7.6e-05	0.64	0
Neutrophil	CD66b	0.057	0.67	0.27	1.5e-09
	CCR7	0.097	0.47	0.46	0
	CD11b	0.6	5e-07	0.72	0
Natural killer cell	XCL1	−0.18	0.17	−0.031	0.49
	CD7	0.031	0.81	0.1	0.028
	KIR3DL1	0.045	0.73	0.069	0.13
Dendritic cell	CD1C	−0.0066	0.96	0.53	0
	CD141	−0.11	0.4	0.18	4.9e-05
	CD11c	0.8	2.6e-14	0.65	0
T cell exhaustion	PDCD1	0.052	0.7	0.25	3.2e-08
	CTLA4	0.055	0.68	0.37	0
	LAG3	−0.097	0.47	0.11	0.013
	TIM-3	0.36	0.0047	0.62	0
Tfh – follicular helper T cell; Th – T helper cell; Treg – regulatory T cell; TAM – tumor-associated macrophage.