31 May 2021: Clinical Research
Association of High-Mobility Group Box 1 (HMGB1) Gene Polymorphisms with Susceptibility and Better Survival Prognosis in Chinese Han Neonatal Necrotizing Enterocolitis
Huiling Cao 1ABCEF , Defeng Guo 2CEF*DOI: 10.12659/MSM.930015
Med Sci Monit 2021; 27:e930015
Table 2 Genotype and allele distributions of the HMGB1 gene rs1045411, rs2249825, and rs1360485 polymorphisms in case and control groups.
| Genotype/allele | Control, n=180 (%) | Case, n=258 (%) | P value | OR (95% CI) |
|---|---|---|---|---|
| GG | 122 (67.8) | 172 (66.7) | Reference | Reference |
| GA | 51 (28.3) | 73 (28.3) | 0.944 | 1.015 (0.663–1.555) |
| AA | 7 (3.9) | 13 (5.0) | 0.568 | 1.317 (0.511–3.398) |
| G | 295 (81.9) | 417 (80.8) | Reference | Reference |
| A | 65 (18.1) | 99 (19.2) | 0.673 | 1.077 (0.762–1.524) |
| 0.569 | 0.160 | – | – | |
| CC | 133 (73.9) | 186 (72.1) | Reference | Reference |
| CG | 41 (22.8) | 64 (24.8) | 0.633 | 1.116 (0.711–1.752) |
| GG | 6 (3.3) | 8 (3.1) | 0.931 | 0.952 (0.323–2.812) |
| C | 307 (85.3) | 436 (84.5) | Reference | Reference |
| G | 53 (14.7) | 80 (15.5) | 0.751 | 1.063 (0.729–1.549) |
| 0.213 | 0.393 | – | – | |
| TT | 93 (51.7) | 163 (63.2) | Reference | Reference |
| TC | 75 (41.7) | 88 (34.1) | ||
| CC | 12 (6.6) | 7 (2.7) | ||
| T | 261 (72.5) | 414 (80.2) | Reference | Reference |
| C | 99 (27.5) | 102 (19.8) | ||
| 0.547 | 0.226 | – | – | |
| HWE – Hardy-Weinberg equilibrium. | ||||