18 August 2020>: Clinical Research
Effects of a Secondary Prevention Combination Therapy with beta-Blocker and Statin on Major Adverse Cardiovascular Events in Acute Coronary Syndrome Patients
Ling Zhu 12ABCDEFG , Qianwei Cui 1BCEF , Ying Liu 3BCEF , Zhongwei Liu 1BCE , Yong Zhang 1BCF , Fuqiang Liu 1ACDEFG* , Junkui Wang 1ACDEFG*DOI: 10.12659/MSM.925114
Med Sci Monit 2020; 26:e925114
Supplementary Table 3 Multivariate COX analysis of ischemia-driven revascularization according to risk category of always beta-blocker and statin treatment.
Ischemia-driven revascularization# | No therapy | beta-Blocker mono-therapy | Statin mono-therapy | Co-therapy |
---|---|---|---|---|
n=139 | n=71 | n=149 | n=277 | |
Model 1a | ||||
HR (95% CI)* | 1.00 | 0.55 (0.26–1.15) | 0.48 (0.26–0.87) | 0.26 (0.14–0.47) |
value* | 0.114 | 0.016 | ||
Model 2b | ||||
HR (95% CI)* | 1.00 | 0.56 (0.26–1.18) | 0.48 (0.26–0.88) | 0.26 (0.15–0.48) |
value* | 0.128 | 0.017 | ||
Model 3c | ||||
HR (95% CI)* | 1.00 | 0.55 (0.26–1.16) | 0.45 (0.24–0.83) | 0.25 (0.14–0.46) |
value* | 0.115 | 0.010 | ||
Model 4d | ||||
HR (95% CI)* | 1.00 | 0.46 (0.22–0.99) | 0.29 (0.15–0.54) | 0.14 (0.08–0.26) |
value* | 0.047 | |||
* Compared with the no therapy group; a Model 1: Unadjusted; b Model 2: Multivariate adjustment was made for age, sex, smoking, body mass index; c Model 3: Multivariate adjustment was made for age, sex, smoking, body mass index, diabetes, hypertension, old myocardial infarction, atrial fibrillation; d Model 4: Multivariate adjustment was made for age, sex, smoking, body mass index, diabetes, hypertension, old myocardial infarction, atrial fibrillation, always use of aspirin, use of clopidogrel at 1 year, always use of ACEI or ARB, revascularization at baseline; # included percutaneous coronary intervention and coronary artery bypass grafting. There were 0 cardiovascular death, 8 myocardial infarction, and 14 stroke during the follow-up. The incidence of cardiovascular death, myocardial infarction, and stroke were low and did not allow for further analysis. CI – confidence interval; HR – hazard ratio. |