23 June 2020: Database Analysis
Bioinformatics-Based Study to Investigate Potential Differentially Expressed Genes and miRNAs in Pediatric Sepsis
Kexin Xie 1BE* , Shan Kong 1CE* , Fuxing Li 1DF , Yulin Zhang 1CD , Jing Wang 2DF , Weidong Zhao 1AG*DOI: 10.12659/MSM.923881
Med Sci Monit 2020; 26:e923881
Supplementary Table 1 GO biological process terms for DEGs between the control and pediatric sepsis groups.
| Index | Name | P-value | Adjusted P-value | Odds ratio | Combined score |
|---|---|---|---|---|---|
| 1 | Neutrophil degranulation (GO: 0043312) | 3.277e-51 | 1.672e-47 | 12.09 | 1405.58 |
| 2 | Neutrophil activation involved in immune response (GO: 0002283) | 5.617e-51 | 1.433e-47 | 11.99 | 1387.48 |
| 3 | Neutrophil mediated immunity (GO: 0002446) | 9.578e-51 | 1.629e-47 | 11.89 | 1369.74 |
| 4 | Membrane raft assembly (GO: 0001765) | 0.00002597 | 0.004734 | 45.25 | 477.76 |
| 5 | Complement receptor mediated signaling pathway (GO: 0002430) | 0.000002892 | 0.001342 | 36.20 | 461.67 |
| 6 | Positive regulation of superoxide anion generation (GO: 0032930) | 0.000004505 | 0.001642 | 32.91 | 405.11 |
| 7 | Immunoglobulin mediated immune response (GO: 0016064) | 0.00007155 | 0.01074 | 33.94 | 323.93 |
| 8 | B cell mediated immunity (GO: 0019724) | 0.00007155 | 0.01106 | 33.94 | 323.93 |
| 9 | Regulation of superoxide anion generation (GO: 0032928) | 0.000009593 | 0.002577 | 27.85 | 321.74 |
| 10 | Immune response-activating cell surface receptor signaling pathway (GO: 0002429) | 0.000002132 | 0.001209 | 22.62 | 295.44 |