Figure 1 Representative case presenting the combined high-cellularity tumor volume (HCTVC) segmented by both T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI), as compared with the metabolic tumor volume (MTV) defined in positron emission tomography with computed tomography (PET/CT). (A) T2WI and (D) manually drawn region of interest (ROI), divided into 3 clusters. (B) Apparent diffusion coefficient (ADC) map and (E) manually drawn ROI, divided into 3 clusters. (C) PET/CT and manually drawn ROI, generated by using 45% maximum standard uptake value as the lower threshold. (F) The HCTVC was obtained by excluding low-intensity pixels on T2WI and high ADC pixels on ADC maps.