02 July 2023 : Review article
Advancements in Zebrafish Models for Breast Cancer Research: Unveiling Biomarkers, Targeted Therapies, and Personalized Medicine
DOI: 10.12659/MSM.940550
Med Sci Monit 2023; 29:e940550
Background
Zebrafish Breast Cancer In Vivo Models
Breast Cancer Patient-Derived Xenografts
Troubleshooting In Vivo Models
Epithelial-Mesenchymal Transition (EMT) in Tumor Metastasis
Modeling Breast Cancer Metastasis with Zebrafish
Importance of TGF-β in the Process of Metastasis
Role of PTEN in Invasion and Migration of Cancer Cells
Role of CXCR4-CXCL12 Chemokine Signaling Axis in Cancer Cell Migration
Metastatic Capacity of Circulating Tumor Cells
Study of Effect of the Microenvironment on Breast Cancer Cells
Zebrafish as a Preclinical Model for Drug Screening
Monoclonal Antibodies Studies in Zebrafish Model
Synthetic Drugs Studies in Zebrafish Model
Natural Products Studies in Zebrafish Model
Future Directions
Conclusions
References