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eISSN: 1643-3750

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Characteristics of Nosocomial Infections in Children Screened for SARS-CoV-2 Infection in China

Jun Shen, Jing Sun, Danyang Zhao, Suyun Li, Weiqiang Xiao, Xian Cai, Jianjiang Yan, Weidong Zhu, Qiaozhi Guo, Xiulan Wen, Jinxia Wu, Xuan Shi, Daoju Jiang, Jing Huang, Jiaming Luo, Huan Chen, Yan Hong, Wencheng Ma, Guangming Liu, Haomei Yang, Qiang Wang, Yongling Song, Jinai Lin, Xin Sun, Peiqing Li

(Suspected Screening Wards, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China (mainland))

Med Sci Monit 2020; 26:e928835

DOI: 10.12659/MSM.928835


BACKGROUND: This study summarizes the characteristics of children screened for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and reports the case of 1 child who was diagnosed with SARS-CoV-2 infection in Guangzhou Women and Children’s Medical Center and the cases of his family members.
MATERIAL AND METHODS: The medical records of 159 children who were admitted to our hospital from January 23 to March 20, 2020, were retrospectively analyzed. Samples from pharyngeal or/and anal swabs were subjected to reverse-transcription polymerase chain reaction (RT-PCR) testing for SARS-CoV-2 within 12 h of patient admission; a second RT-PCR test was done 24 h after the first test.
RESULTS: Of the 159 patients, 151 patients had epidemiological histories, 14 patients had cluster onset, and 8 patients had no epidemiological history but had symptoms similar to coronavirus disease 2019 (COVID-19). The most common symptom was fever (n=125), followed by respiratory and gastrointestinal symptoms. A 7-year-old boy in a cluster family from Wuhan was confirmed with asymptomatic SARS-CoV-2 infection with ground-glass opacity shadows on his lung computed tomography scan, and his swab RT-PCR test had not turned negative until day 19 of his hospitalization. In patients who did not test positive for SARS-CoV-2, influenza, respiratory syncytial virus, and adenovirus were observed. A total of 158 patients recovered, were discharged, and experienced no abnormalities during follow-up.
CONCLUSIONS: For SARS-CoV-2 nosocomial infections, taking a “standard prevention & contact isolation & droplet isolation & air isolation” strategy can prevent infection effectively. Children with clustered disease need close monitoring.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
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