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Medical Science Monitor Basic Research


eISSN: 1643-3750

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Relationship Between IL-10 Gene Polymorphism and Spinal Tuberculosis

Jinming Ma, Zhongzhe Lv, Jianchuan Wang, Jianmin Lu

(Department of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China (mainland))

Med Sci Monit 2019; 25:4901-4906

DOI: 10.12659/MSM.914039

BACKGROUND: To investigate the relation between interleukin-10 (IL-10) gene rs1800871 (A/G) polymorphism and spinal tuberculosis.
MATERIAL AND METHODS: A total of 129 patients with spinal tuberculosis (spinal tuberculosis group) and 106 healthy subjects receiving physical examination (control group) were enrolled in this study. The general data of these subjects were collected, and the C-reactive protein, erythrocyte sedimentation rate (ESR) and baseline hematologic function were examined. The rs1800871 (A/G) polymorphism in IL-10 gene was detected by TaqMan-MGB probe method.
RESULTS: The C-reactive protein, ESR, white blood cell count, absolute neutrophil count and relative neutrophil count in spinal tuberculosis group were higher than those in control group, while the absolute lymphocyte count and relative lymphocyte count were lower than those in control group (p<0.05). Compared with AA genotype, GG and AG+GG genotypes showed statistically significant difference in distribution frequency (p<0.05), but no significant difference was detected between AG genotype and AA genotype (p>0.05). In spinal tuberculosis group, the frequency of G allele was higher than that of A allele (p<0.01). The C-reactive protein, ESR, white blood cell count and relative neutrophil count in GG genotype were increased compared with those in AG+GG genotype (p<0.05).
CONCLUSIONS: The rs1800871 (A/G) polymorphism in IL-10 gene is related to the susceptibility to spinal tuberculosis. Moreover, carrying G allele increases the risk of spinal tuberculosis.

Keywords: Polymorphism, Single Nucleotide, Receptors, Interleukin-10, Tuberculosis, Spinal

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