Scimago Lab
powered by Scopus
call: +1.631.470.9640
Mon-Fri 10 am - 2 pm EST


eISSN: 1643-3750

Get your full text copy in PDF

Prognostic Value and Clinicopathologic Features of Platelet Distribution Width in Cancer: A Meta-Analysis

Wenjie Xia, Wuzhen Chen, Jiangfeng Tu, Chao Ni, Kexin Meng

(Department of Thyroid and Breast Surgery, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, China (mainland))

Med Sci Monit 2018; 24:7130-7136

DOI: 10.12659/MSM.913040

BACKGROUND: The association between platelet distribution width (PDW) and cancer has been evaluated by a few studies, but the influence of PDW on cancer prognosis is unclear. Therefore, we conducted the present meta-analysis.
MATERIAL AND METHODS: We identified relevant research using identical search strategies. The influence of PDW level on cancer prognosis, as well as clinical characteristics, was analyzed.
RESULTS: A total of 11 studies comprising 2625 cancer patients were included in our meta-analysis. The results suggested that high PDW level was obviously related to poor OS (HR=1.54, 95%CI 1.18–2.00), especially for breast cancer (HR=1.21, 95%CI 1.07–1.36) and pharyngolaryngeal cancer (HR=3.06, 95%CI 1.68–5.57). Furthermore, high PDW was obviously related to poor OS both in older and younger subgroups, with combined HR estimates of 1.58 (95%CI 1.15–2.16) and 1.64 (95%CI 1.19–2.26), respectively. High PDW level was notably related to poor OS in the cut-off value ³16% subgroup (HR=1.84, 95%CI 1.01–3.40). Moreover, high PDW level was obviously associated with lymph node metastasis (OR=1.43, 95%CI 1.04–1.99).
CONCLUSIONS: The findings of this study suggest that PDW is an effective and convenient indicator of cancer prognosis. Furthermore, high PDW level is obviously associated with lymph node metastasis.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
I agree