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Impact of Hyperbaric Oxygen on Tissue Healing around Dental Implants in Beagles

Juan Liao, Meng-Jun Wu, Yan-Dong Mu, Peng Li, Jun Go

(Department of Stomatology, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu, Sichuan, China (mainland))

Med Sci Monit 2018; 24:8150-8159

DOI: 10.12659/MSM.912784

BACKGROUND: The impact of hyperbaric oxygen (HBO) on the healing of soft tissues around dental implants was studied in a beagle model.
MATERIAL AND METHODS: Beagle dogs were randomized to receive implants, followed by postoperative HBO therapy or not (n=10 per group). On postoperative days 3, 7, and 14, tissue specimens were paraffin-embedded and analyzed by hematoxylin-eosin and Masson staining, as well as immunohistochemistry against CD31.
RESULTS: Scores for inflammation pathology based on hematoxylin-eosin staining and mean optical density of collagen fibers were significantly different between the HBO and control groups on postoperative days 3 and 7 (P<0.05), but not on day 14. Mean optical density due to anti-CD31 staining was significantly higher in the HBO group on postoperative days 3, 7, and 14 (P<0.05).
CONCLUSIONS: These results suggest that HBO may promote early osteogenesis and soft tissue healing after implantation.

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