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Effect of Age on Prognosis of Gastric Signet-Ring Cell Carcinoma: A SEER Database Analysis

Jun Ren, Gengming Niu, Xin Wang, Tao Song, Zhiqing Hu, Chongwei Ke

(Department of General Surgery, Shanghai Fifth People’s Hospital, Fudan University, Shanghai, China (mainland))

Med Sci Monit 2018; 24:8524-8532

DOI: 10.12659/MSM.911766

BACKGROUND: Age is a prognostic factor for multiple malignancies. In this study, we aimed to assess the effect of age on the cancer-specific survival (CSS) of patients with gastric signet-ring cell carcinoma (SRC).
MATERIAL AND METHODS: Information on patients with gastric SRC was extracted from the Surveillance, Epidemiology, and End Results database. Chi-squared tests were used to demonstrate distribution differences, and Kaplan-Meier analysis and Cox regression models were used to analyze the impact of age on CSS.
RESULTS: A total of 4596 patients were enrolled and divided into 3 subgroups according to age (<45, 45–74, and >74 years old). Higher percentages of T4, N2, and M1 disease were observed in the <45-year-old group (all P<0.001). Kaplan-Meier plots showed that the youngest group had the most favorable 5-year CSS rate (36.3%), which remained true after stratification according to tumor stage. Multivariate Cox regression models demonstrated a poorer survival outcome for >74-year-old than for <45-year-old patients (hazard ratio 1.841, 95% confidence interval 1.636–2.071; P<0.001).
CONCLUSIONS: Young age is associated with improved survival, even though younger patients generally present with a more advanced-stage disease.

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