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Medical Science Monitor Basic Research


eISSN: 1643-3750

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Thrombophilia and Recurrent Pregnancy Loss: The Enigma Continues

Mert Ulaş Barut, Murat Bozkurt, Mehmet Kahraman, Engin Yıldırım, Necat Imirzalioğlu, Ayhan Kubar, Sibel Sak, Elif Ağaçayak, Tarık Aksu, Hakan Çoksüer

(Department of Obstetrics and Gynecology, Harran University School of Medicine, Şanlıurfa, Turkey)

Med Sci Monit 2018; 24: CLR4288-4294

DOI: 10.12659/MSM.908832

BACKGROUND: Thrombophilic gene polymorphism is known to be a risk factor for recurrent pregnancy loss (RPL), but few studies have confirmed a possible role of thrombophilic genes polymorphism in RPL risk. This study was conducted to understand the relationship of the mutations of some thrombophilia-associated gene polymorphism (heterozygous/homozygous) with RPL. We compared patients with 2 abortions to patients with 3 or more abortions among Turkish women.
MATERIAL AND METHODS: In this study, patients previously diagnosed with habitual abortus at Obstetrics and Gynecology outpatient clinics in Turkey between 2012 and 2016 were included. In their peripheral blood, we detected factor V Leiden H1299R, prothrombin G20210A, MTHFR C677T, MTHFR A1298C, PAI-1 4G/5G, and PAI-1 4G/4G gene mutations.
RESULTS: In this study, we have observed statistically meaningful data (P<0.01) related to the relationship between RPL and thrombophilia-associated gene polymorphisms such as heterozygous factor V Leiden H1299R, heterozygous prothrombin G20210A, PAI-1 4G/5G, and PAI-1 4G/4G.
CONCLUSIONS: We found that diagnosis of thrombophilic genes polymorphism is useful to determine the causes of RPL, recognizing that this multifactorial disease can also be influenced by various acquired factors, including reproduction-associated risk factors and prolonged immobilization.

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