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eISSN: 1643-3750

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Correlation Between Pigment Epithelium-Derived Factor (PEDF) level and Degree of Coronary Angiography and Severity of Coronary Artery Disease in a Chinese Population

Man Li, Shuxia Wang, Yan Zhang, Shouyuan Ma, Ping Zhu

(Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China (mainland))

Med Sci Monit 2018; 24: CLR1751-1758

DOI: 10.12659/MSM.908534


BACKGROUND: The role of pigment epithelium-derived factor (PEDF) in protection of coronary artery disease (CAD) remains controversial. The aim of this study was to reassess the value of PEDF in predicting the severity and prognosis of newly diagnosed stable CAD in a Chinese population.
MATERIAL AND METHODS: Plasma PEDF levels were measured in 259 stable CAD patients undergoing coronary angiography and 116 age- and sex-matched healthy controls. The severity of coronary atherosclerosis was assessed using Gensini score.
RESULTS: PEDF levels were significantly lower in CAD patients than in healthy subjects (5.856±0.790 vs. 6.658±1.070 μg/ml, respectively, p<0.01). Stepwise regression analysis showed a negative correlation between PEDF levels and severity of CAD as quantified by Gensini score value (β=–0.626, p<0.01).
CONCLUSIONS: Our study showed that plasma PEDF levels were significantly lower in CAD patients than in controls, and the plasma PEDF levels may be used as a potential predicator for coronary severity.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
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