13 March 2018 : Clinical Research
Cytokine, C-Reactive Protein, and Heat Shock Protein mRNA Expression Levels in Patients with Active Behçet’s Uveitis
Eda Balkan1ACEF*, Handan Bilen2B, Nilnur Eyerci3AB, Sadullah Keleş4B, Aslı Kara5BC, Necmettin Akdeniz6B, Hasan Dogan1CDOI: 10.12659/MSM.907918
Med Sci Monit 2018; 24: CLR1511-1516
Abstract
BACKGROUND: To investigate the gene expression levels of interleukin 10 (IL10), IL18, interferon gamma (IFNG), IFN-gamma receptor (IFNGR), C-reactive protein (CRP), and heat shock protein 70 (HSP70) in patients with active Behçet’s uveitis.
MATERIAL AND METHODS: Forty patients with Behçet’s disease diagnosed according to the International Study Group criteria and 30 healthy individuals were included in the study. IL10, IL18, IFNG, IFNGR, CRP, and HSP70 gene expression levels were compared.
RESULTS: Expression levels of IL18, IFNG, IFNGR, and CRP were significantly higher in patients with active Behçet’s uveitis than in control subjects (P<0.01 for all), whereas no significant differences were found in IL10 and HSP70 gene expression levels (P>0.01 for both).
CONCLUSIONS: IL18, IFNG, IFNGR, and CRP gene expression is significantly increased in active Behçet’s uveitis. There was no significant difference between active Behçet’s uveitis patients and controls in terms of IL10 and HSP70 gene expression levels. We conclude that drugs prescribed to Behçet’s patients with active uveitis downregulate gene expression.
Keywords: Behcet Syndrome, HSC70 Heat-Shock Proteins, Interleukins
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