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Medical Science Monitor Basic Research


eISSN: 1643-3750

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Liver Disease During Pregnancy: A Challenging Clinical Issue

Ivana Mikolasevic, Tajana Filipec-Kanizaj, Ivan Jakopcic, Iva Majurec, Alemka Brncic-Fischer, Nikola Sobocan, Irena Hrstic, Tea Stimac, Davor Stimac, Sandra Milic

(Department of Gastroenterology, University Hospital Center (UHC) Rijeka, School of Medicine, University of Rijeka, Rijeka, Croatia)

Med Sci Monit 2018; 24: REV4080-4090

DOI: 10.12659/MSM.907723

ABSTRACT: One of the least studied topics in the field of obstetrics is liver disease during pregnancy, which creates a challenge for both gynecologists and hepatologists. Approximately 3% of pregnant women are affected by some form of liver disease during pregnancy. Some of these conditions can be fatal for both the mother and child. In addition, 3 types of liver disease need to be differentiated during pregnancy. One type is liver disease directly related to pregnancy, which can occur at a specific time during pregnancy. Another type is liver disease not related to pregnancy, which can occur at any time, such as viral- or drug-induced hepatitis. Furthermore, pregnancy can occur in women with pre-existing liver disease. It is essential that the clinicians are familiar with this disorder so they can respond promptly and appropriately in all of these situations, especially when emergency delivery is needed and must not be postponed.

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