30 June 2017 : Laboratory Research
Transcription Factor 21 (TCF21) rs12190287 Polymorphism is Associated with Osteosarcoma Risk and Outcomes in East Chinese Population
Zhenghui Jiang1ABCE*, Weikang Zhang1CD, Zhikang Chen2EF, Jinxiang Shao1BD, Liqiu Chen1CDE, Zhaohui Wang3EGDOI: 10.12659/MSM.905595
Med Sci Monit 2017; 23:3185-3191
Abstract
BACKGROUND: The transcription factor 21 (TCF21) gene is believed to be a tumor suppressor gene. TCF21 gene polymorphisms were found to play a role in the tumorigenesis of some solid malignancies. We raised a hypothesis that genetic polymorphisms of TCF21 were correlated with risk and prognosis of osteosarcoma.
MATERIAL AND METHODS: We recruited 225 young osteosarcoma individuals and 250 cancer-free controls. Five tagging SNPs (TCF21 rs2327429 T>C, rs2327433 A>G, rs2327433 A>G, rs12190287 C>G, and rs4896011 T>A) were genotyped. Preserved DNA samples from blood underwent PCR analysis for genotyping.
RESULTS: rs12190287 C>G is a good predictor of osteosarcoma risk and outcomes. The CG and GG genotypes of rs12190287 predict elevated risk of osteosarcoma. Besides, rs12190287 CG and GG genotypes are associated with Enneking stage and potential in forming metastasis of osteosarcoma.
CONCLUSIONS: Genetic polymorphisms of TCF21 are potentially predictive for osteosarcoma risk and outcomes.
Keywords: Polymorphism, Single Nucleotide
Editorial
01 July 2026 : Editorial
Editorial: The WHO Identifies Ebola Disease Due to Bundibugyo Virus as a Public Health Emergency of International Concern (PHEIC) as Vaccine Development Accelerates
DOI: 10.12659/MSM.954627
Med Sci Monit 2026; 32:e954627
In Press
Clinical Research
Association Between Total Cholesterol–to–High-Density Lipoprotein Ratio and Gestational Hypertension: A Cas...Med Sci Monit In Press; DOI: 10.12659/MSM.952395
Review article
Clinical Use of Endotracheal Intubation Without Neuromuscular Blockade: The Current Stage of KnowledgeMed Sci Monit In Press; DOI: 10.12659/MSM.951765
Clinical Research
Effect of Dexmedetomidine Hydrochloride Nasal Spray on Anxiety and Sleep in Patients Undergoing Gynecologic...Med Sci Monit In Press; DOI: 10.12659/MSM.952465
Clinical Research
Prognostic Value of Mortality Scoring Systems in Patients With Severe Burns: Identifying Key Predictors of ...Med Sci Monit In Press; DOI: 10.12659/MSM.951713
Most Viewed Current Articles
17 Jan 2024 : Review article 14,176,173
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
13 Nov 2021 : Clinical Research 3,757,769
Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788
Med Sci Monit 2021; 27:e932788
14 Dec 2022 : Clinical Research 2,466,143
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research 708,797
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387