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Medical Science Monitor Basic Research
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eISSN: 1643-3750

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Association of Immune Factors with Drug-Resistant Tuberculosis: A Case-Control Study

En-Tao Sun, Dan Xia, Ben-He Li, Jun Ma, Yuan-Yuan Dong, Shu-Shu Ding, Bai-Feng Chen, Yu-Feng Wen

(School of Public Health, Wannan Medical College, Wuhu, Anhui, China (mainland))

Med Sci Monit 2017; 23:5330-5336

DOI: 10.12659/MSM.904309


BACKGROUND: Presently, studies of factors associated with drug-resistant tuberculosis (TB) focus on patients’ socio-demographic characteristics and living habits, to the exclusion of biochemical indicators, especially immune factors. This study was carried out to determine whether immune factors are associated with drug-resistant TB.
MATERIAL AND METHODS: A total of 227 drug-resistant pulmonary TB patients and 225 drug-susceptible pulmonary TB patients were enrolled in this study. Information on socio-demographic characteristics and biochemical indicators were obtained through their clinical records. Non-conditional logistic regression was used to analyze the association of these indicators with drug-resistant TB.
RESULTS: There were significant differences in re-treatment, marital status, alanine aminotransferase (ALT), blood uric acid (BUA), carcino-embryonic antigen (CEA), T-spot, and CD3 and CD4 counts between the 2 groups. In multivariable analysis, re-treatment [Odds Ratio (OR)=5.290, 95% Confidence Interval [CI]=2.652–10.551); CD3 (OR=1.034, 95% CI=1.001–1.068); CD4 (OR=1.035, 95% CI =1.001–1.070) and IgM (OR=1.845, 95% CI=1.153–2.952) were associated with drug-resistant TB.
CONCLUSIONS: These results suggest the need for greater attention to re-treatment cases and immune function when treating drug-resistant TB.

Keywords: Drug Resistance, Bacterial, Immunity, Cellular, Retreatment, Tuberculosis, Pulmonary

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
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