19 July 2017 : Clinical Research
Preoperative Anemia as a Simple Prognostic Factor in Patients with Urinary Bladder Cancer
Cheng Chen1EF, Linkun Hu1BDF, Xiangxiang Li2BC, Jianquan Hou1AC*DOI: 10.12659/MSM.902855
Med Sci Monit 2017; 23:3528-3535
Abstract
BACKGROUND: To evaluate the incidence of preoperative anemia and its prognostic role in patients with urinary bladder cancer (BC).
MATERIAL AND METHODS: A total of 317 patients diagnosed with BC were enrolled in this retrospective cohort study. Univariate and multivariate analysis was used to identify independent prognostic factors and Kaplan-Meier survival analysis was applied to examine the influence of anemia on survival.
RESULTS: 109 patients (34.4%) were anemic with a median preoperative hemoglobin of 114 g/L (interquartile range 104 to 122.5). After a median of 6 years follow-up (range: 2 to 8 years), the median recurrence-free survival (RFS), progression-free survival (PFS), and overall survival (OS) in anemic patients were significantly lower than non-anemic patients (p≤0.001). Multivariate Cox analysis indicated that anemia remained an independent predictor of RFS and OS (p=0.010, 0.007).
CONCLUSIONS: Anemic patients with BC are likely to have a shorter RFS and OS than non-anemic patients, and anemia is an independent predictor of RFS and OS.
Keywords: Anemia
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