31 May 2017 : Clinical Research
Necl 4 and RNAse 5 Are Important Biomarkers for Gastric and Colon Adenocarcinomas
İlyas Sayar1ABCDEFG*, Aysun Gökçe2ABDEF, Levent Demirtas3ABCFG, Hüseyin Eken4BDFG, Ferda Keskin Çimen1BDFG, Orhan Çimen4BDFGDOI: 10.12659/MSM.902648
Med Sci Monit 2017; 23:2654-2659
Abstract
BACKGROUND: There is a need to identify new prognostic factors that may be used in addition to the known risk factors in gastrointestinal adenocarcinomas. In this study, we aimed to determine the expression of Necl 4 and RNase 5 biomarkers in gastric and colon adenocarcinomas, as well as the prognostic efficacy of these biomarkers in gastric and colon adenocarcinomas.
MATERIAL AND METHODS: Ninety-two cases resected due to stomach and colon adenocarcinoma were included in the study. The expression of Necl 4 and RNase 5 biomarkers was evaluated by immunohistochemical staining of the stomach and colon normal mucosa and adenocarcinoma areas.
RESULTS: In colon adenocarcinomas, there was a significant association between Necl 4 and lymphovascular invasion, vascular invasion, and perineural invasion (p<0.05). There was a significant association between RNase 5 and histological differentiation in colon adenocarcinomas (p<0.05). There was no association between RNase 5 and Necl 4 in gastric or colon adenocarcinomas.
CONCLUSIONS: Necl 4 may have prognostic value in colon adenocarcinomas, but it is difficult to ascertain in gastric adenocarcinomas.
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