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eISSN: 1643-3750

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Effect of Naringin on Monosodium Iodoacetate-Induced Osteoarthritis Pain in Rats

Qiang Xu, Zuo-fu Zhang, Wei-xue Sun

(Department of Joint Surgery, Yantai Yu Huang Ding Hospital, Yantai, Shandong, China (mainland))

Med Sci Monit 2017; 23:3746-3751

DOI: 10.12659/MSM.902396


BACKGROUND: The aim of the current study was to evaluate the anti-osteoarthritic and anti-inflammatory effect of naringin in a monosodium iodoacetate (MIA)- induced osteoarthritis (OA) model in rats. The anti-osteoarthritic potential of naringin was evaluated against the MIA-induced OA rat model.
MATERIAL AND METHODS: Wistar rats were used for the study and were divided into the following groups: normal control (saline-treated); group II (MIA-treated): group III (MIA+Naringin), and group IV (MIA+Indomethacin). The potential effect of naringin was evaluated via its effect on the level of proinflammatory cytokines, measuring the weight-bearing distribution, and histopathological analysis.
RESULTS: The anti-inflammatory effect of naringin was assessed in vitro in lipopolysaccharide-induced RAW 264.6 cells. The results suggest that naringin exerts an anti-inflammatory effect via reducing the production of the prostaglandin E2 (PGE2), nitric oxide (NO), interlukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in LPS-induced RAW cells. Additionally, naringin also supported the recovery of hind-limb weight-bearing, reduced the generation or production of inflammatory mediator and proinflammatory cytokines, and protected the tissue from the damage in the OA model.
CONCLUSIONS: Naringin appears to be an effective therapeutic drug for the treatment of the OA and OA-related symptoms.

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