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24 August 2016 : Original article  

Membrane Glycolipids Content Variety in Gastrointestinal Tumors and Transplantable Hepatomas in Mice

Jun LvABCDEF, Can Qun LvAC, Bo-Liang WangC, Ping MeiD, Lei XuB

DOI: 10.12659/MSMBR.899635

Med Sci Monit Basic Res 2016; 22:87-90

Abstract

BACKGROUND: The aim of this study was to investigate the variety of plasma contents of membrane glycolipids in 65 gastrointestinal tumors and 31 transplant hepatomas in mice.

MATERIAL AND METHODS: The experimental model was a transplantable murine hepatoma. Experimental mice were divided into 3 groups.

RESULTS: The LSA and TSA content in the 2 groups were significantly difference (p<0.01), and were significantly lower in the therapeutic group than in the control group (p<0.01).

CONCLUSIONS: These results indicate that membrane glycolipids index LSA and TSA are sensitive markers in gastrointestinal tumors. In the transplanted hepatomas in mice, they may be considered as ancillary indicators for judging the therapeutic effect of hepatoma.

Keywords: G(M3) Ganglioside, Intestinal Neoplasms, Membrane Glycoproteins

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Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416