12 October 2016 : Laboratory Research
MiR-940 Inhibited Cell Growth and Migration in Triple-Negative Breast Cancer
Lingmi HouBC, Maoshan ChenE, Hongwei YangAD, Tianyong XingEF, Jingdong LiC, Guangwu LiBC, Lina ZhangB, Shishan DengCEG, Jiani HuBC, Xiaobo ZhaoG, Jun JiangGDOI: 10.12659/MSM.897731
Med Sci Monit 2016; 22:3666-3672
Abstract
BACKGROUND: Breast cancer is the main type of cancer in women, and triple-negative breast cancer (TNBC) is a unique subtype of breast cancer. The expression of miR-940 has been shown to play an important role in various cancers; however, the role of miR-940 in TNBC remains unknown.
MATERIAL AND METHODS: The expression of miR-940 in TNBC tissues or cells were tested by qRT-PCR; the expression of miR-940 in cells were overexpressed by miR-940 mimics, and suppressed by anti-miR-940. Bioinformatics algorithms from TargetScanHuman were used to predict the target genes of miR-940. The interaction between miR-940 and ZNF24 was confirmed by dual luciferase assays. The protein level was assayed by Western blot.
RESULTS: TNBC tissues and cells showed lower miR-940 levels.
CONCLUSIONS: MiR-940 inhibited cellular proliferation and migration in TNBC.
Keywords: Kruppel-Like Transcription Factors - metabolism, Triple Negative Breast Neoplasms - pathology
Editorial
01 July 2026 : Editorial
Editorial: The WHO Identifies Ebola Disease Due to Bundibugyo Virus as a Public Health Emergency of International Concern (PHEIC) as Vaccine Development Accelerates
DOI: 10.12659/MSM.954627
Med Sci Monit 2026; 32:e954627
In Press
Review article
Clinical Use of Endotracheal Intubation Without Neuromuscular Blockade: The Current Stage of KnowledgeMed Sci Monit In Press; DOI: 10.12659/MSM.951765
Clinical Research
Effect of Dexmedetomidine Hydrochloride Nasal Spray on Anxiety and Sleep in Patients Undergoing Gynecologic...Med Sci Monit In Press; DOI: 10.12659/MSM.952465
Clinical Research
Prognostic Value of Mortality Scoring Systems in Patients With Severe Burns: Identifying Key Predictors of ...Med Sci Monit In Press; DOI: 10.12659/MSM.951713
Laboratory Research
Evaluation of the Trueness and Precision of Cast, Milled-Cast, Milled, and 3D-Printed Post-and-Core Techniq...Med Sci Monit In Press; DOI: 10.12659/MSM.953491
Most Viewed Current Articles
17 Jan 2024 : Review article 14,176,214
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
13 Nov 2021 : Clinical Research 3,757,839
Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788
Med Sci Monit 2021; 27:e932788
14 Dec 2022 : Clinical Research 2,466,153
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research 708,809
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387