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Medical Science Monitor Basic Research


eISSN: 1643-3750

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Thin-Section Computed Tomography Manifestations During Convalescence and Long-Term Follow-Up of Patients with Severe Acute Respiratory Syndrome (SARS)

Xiaohua Wu, Dawei Dong, Daqing Ma

(Department of Radiology, Beijng Friendship Hospital, Capital Medical University, Beijng, China (mainland))

Med Sci Monit 2016; 22:2793-2799

DOI: 10.12659/MSM.896985

BACKGROUND: SARS is not only an acute disease, but also leads to long-term impaired lung diffusing capacity in some survivors. However, there is a paucity of data regarding long-term CT findings in survivors after SARS. The aim of this study was to assess the changes in lung function and lung thin-section computed tomography (CT) features in patients recovering from severe acute respiratory syndrome (SARS), especially the dynamic changes in ground-glass opacity (GGO).
MATERIAL AND METHODS: Clinical and radiological data from 11 patients with SARS were collected. The serial follow-up thin-section CTs were evaluated at 3, 6, and 84 months after SARS presentation. The distribution and predominant thin-section CT findings of lesions were evaluated.
RESULTS: The extent of the lesions on the CT scans of the 11 patients decreased at 6 and 84 months compared to 3 months. The number of segments involved on 84-month follow-up CTs was less than those at 6 months (P<0.05). The predominant thin-section CT manifestation at 84 months (intralobular and interlobular septal thickening) was different than that at 6 months, at which GGO was predominant.
CONCLUSIONS: During convalescence after SARS, GGO and intralobular and interlobular septal thickening were the main thin-section CT manifestation. Intralobular and interlobular septal thickening predominated over GGO at 84 months.

Keywords: Convalescence, Adult, Follow-Up Studies, Longitudinal Studies, Lung - physiopathology, Respiratory Function Tests, Severe Acute Respiratory Syndrome - physiopathology, Tomography, X-Ray Computed - methods

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