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eISSN: 1643-3750

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T-SPOT.TB in Detection of Active Tuberculosis During Pregnancy: A Retrospective Study in China

Qiaopei Chen, Xuxiao Guo, Xinfeng Wang, Maoshui Wang

(Department of Clinical Laboratory, Guangxi Maternal and Child Health Hospital, Nanning, Guangxi, China (mainland))

Med Sci Monit 2016; 22:57-60

DOI: 10.12659/MSM.896943


BACKGROUND: Interferon-gamma release assays have not been validated in active TB among pregnant women. Therefore, the objective of this retrospective study was to estimate the diagnostic value of T-SPOT.TB in active TB among pregnant women.
MATERIAL AND METHODS: Between May 2012 and May 2015, 26 consecutive pregnant women with suspected TB were enrolled in our study. The clinicopathological characteristics and T-SPOT.TB results were reviewed and analyzed.
RESULTS: Pregnant patients were divided into a TB group (n=21) and a Non-TB group (n=5). In the TB group, 5 patients had pulmonary TB, 5 had pulmonary TB+ extrapulmonary TB, and 11 had exclusively extrapulmonary TB. The most common site of extrapulmonary TB was pleural (n=11). Statistical analysis showed that the lymphocyte count in the TB group was lower than in the Non-TB group (P<0.05). For detection of active TB during pregnancy, T-SPOT.TB had a high sensitivity of 100.0% (84.5%–100.0%) and a specificity of 80.0% (37.6–96.4%).
CONCLUSIONS: T-SPOT.TB shows good performance in detection of active tuberculosis during pregnancy. Interferon gamma release assay for TB screening of pregnant women is recommended in clinical practice because it may be a more appropriate diagnostic tool than the tuberculin skin test.

Keywords: China, Adult, Interferon-gamma Release Tests, Lymphocyte Count, Mycobacterium tuberculosis, Pregnancy, Pregnancy Complications, Infectious - diagnosis, Sensitivity and Specificity, Tuberculin Test, Tuberculosis - diagnosis

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
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