Scimago Lab
powered by Scopus
call: +1.631.470.9640
Mon-Fri 10 am - 2 pm EST


Medical Science Monitor Basic Research


eISSN: 1643-3750

Get your full text copy in PDF

Elevated Whole-Blood Viscosity is Associated with Gallstones

Ji-bin Yin, Ying Li, Tiemin Liu, Rui-tao Wang

(Department of Gastroenterology, The Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China (mainland))

Med Sci Monit 2015; 21:3847-3852

DOI: 10.12659/MSM.895373

BACKGROUND: Gallstones are associated with dyslipidemia, metabolic syndrome, hyperinsulinemia, and carotid intima-media thickness, which all are related to hyperviscosity. Therefore, this study aimed to examine the associations between blood viscosity and gallstones.
MATERIAL AND METHODS: We investigated the associations between blood viscosity and gallstones in a study conducted in middle-aged subjects.
RESULTS: Among 849 enrolled patients, 421 (49.6%) had gallstone disease. Compared with control subjects, whole-blood viscosity (WBV) levels were increased in patients with gallstones. The prevalence of gallstones increased as WBV (3 sā€“1) quartiles increased. Furthermore, logistic regression analysis showed that WBV (3 sā€“1) was associated with gallstone disease.
CONCLUSIONS: We found that whole-blood viscosity at low shear rate was independently associated with gallstones. Whether control of hyperviscosity would reduce the risk of developing gallstones deserves further investigation.

Keywords: Blood Viscosity, Gallstones, Risk Factors

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
I agree