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eISSN: 1643-3750

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Admission Glucose and Risk of Early Death in Non-Diabetic Patients with ST-Segment Elevation Myocardial Infarction: A Meta-Analysis

Cheng-jin Zhao, Zhen-xuan Hao, Rong Liu, Yang Liu

(Department of Emergency, Shaanxi Provincial People’s Hospital, Xi’an, Shaanxi, China (mainland))

Med Sci Monit 2015; 21:1387-1394

DOI: 10.12659/MSM.894249


BACKGROUND: Impaired admission glucose (AG) is considered to significantly increase risk on both early and late death of the patients with ST-segment elevation myocardial infarction (STEMI), especially for non-diabetic patients; however, some reports contradict the relationship. We therefore conducted a meta-analysis to clarify this issue.
MATERIAL AND METHODS: PubMed, EMBASE, Web of Science, and Cochrane Library databases were systematically searched to identify all related prospective cohort studies. The relative risks (RR) with their 95% confidence interval (CI) were pooled quantitatively.
RESULTS: The pooled RR of early outcome events indicated patients with glucose concentrations ≥6.1–11.1 mmol/L had a 4.38-fold (95% CI, 3.23–5.94) higher early mortality. The pooled RR of late outcome events indicated that the patients with glucose concentrations ≥7.8-11.1 mmol/L had a 1.65-fold (95% CI, 1.33–2.04) higher late mortality based on in-hospital or 30-day survivors.
CONCLUSIONS: High AG may be a helpful prognostic marker of significantly increased risk on early death in non-diabetic patients with STEMI, and has an explicit but prognostic adverse impact on long-term mortality but not early mortality in these patients.

Keywords: Blood Glucose - analysis, Electrocardiography, Hospital Mortality, Hyperglycemia - mortality, Myocardial Infarction - therapy, Patient Admission, Prognosis, Prospective Studies, Risk, Survival Analysis, Time Factors

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
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