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Medical Science Monitor Basic Research
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eISSN: 1643-3750

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Correlation of IL-17 Level in Synovia and Severity of Knee Osteoarthritis

Yingsong Liu, Hao Peng, Zhao Meng, Mingzhu Wei

(Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei, China (mainland))

Med Sci Monit 2015; 21:1732-1736

DOI: 10.12659/MSM.893771


BACKGROUND: The aim of this study was to evaluate the role of interleukin-17 (IL-17) level in synovia and its relationship with the severity of knee osteoarthritis (OA).
MATERIAL AND METHODS: We enrolled 226 OA patients and 106 controls in this study. The symptomatic/radiation severity of OA was assessed by the Western Ontario McMaster University Osteoarthritis Index (WOMAC) pain score/Kellgren-Lawrence (KL) grading system. Serum IL-17 levels were measured by enzyme-linked immunosorbent assay (ELISA).
RESULTS: Synovia IL-17 levels were significantly higher in OA patients compared with controls (P<0.01), and were negatively correlated with OA severity. IL-17 level gradually decreased among different phases but lacked statistical significance.
CONCLUSIONS: IL-17 might play a crucial role in the pathogenesis of OA and is closely related to pain. Blocking the IL-17 signaling pathway may delay pain related to OA.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
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