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Correlations between Drug Resistance of Beijing/W Lineage Clinical Isolates of Mycobacterium tuberculosis and Sublineages: A 2009–2013 Prospective Study in Xinjiang Province, China

Xian-hua Wang, Ai-guo Ma, Xiu-xia Han, Xiao-ming Gu, Li-ping Fu, Peng-gang Li, Fen-yu Li, Qiu-zhen Wang, Hui Liang, Abudu Katar, Li-jie Wang

(School of Public Health, Medical College, Qingdao University, Qingdao, Shandong, China (mainland))

Med Sci Monit 2015; 21:1313-1318

DOI: 10.12659/MSM.892951

Background: The prevalence of drug-resistant tuberculosis (TB) in Xinjiang is higher than in other regions of China, and Beijing/W lineage Mycobacterium tuberculosis (MTB) is the dominant strain of MTB in Xinjiang. However, information on multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB, particularly the correlation between MDR and the Beijing/W lineage and the correlation between drug resistance and the Beijing/W sublineage strains, is limited.
Material and Methods: We conducted a prospective study to describe the prevalence of MDR/XDR TB, Beijing/W lineage and sublineage strains in Xinjiang in China from 2009 to 2013. All MTB underwent drug susceptibility testing to the first- and second-line anti-tuberculosis drugs. The Beijing/W lineages and sublineages were detected by large-sequence polymorphisms with polymerase chain reaction.
Results: A total of 410 clinical isolates were identified. The overall percentage of MDR and XDR cases in Xinjiang was 13.2% (54/410) and 13.0% (7/54), respectively. Overall, 9.8% (14/143) of the Beijing lineage MTB were MDR patients, and 15.6% (40/257) of the Non-Beijing lineage MTB were MDR patients. In the 143 Beijing MTB lineages, 11.2% isolates were in sublineage 105, 15.4% isolates were in sublineage 207, 69.2% isolates were in sublineage 181, and 4.2% isolates were in sublineage 150. None of the isolates were detected in sublineage 142. Significant differences between the Beijing/W and non-Beijing/W strains were observed regarding INH and EMB resistance, respectively.
Conclusions: The prevalence of the MDR TB in Xinjiang remains high and imposes challenges for TB control. Four Beijing/W sublineage isolates were observed in Xinjiang. There was no correlation between MDR and the Beijing/W lineage and no correlation between drug resistance and the Beijing/W sublineage strains. Surveillance of the clinical isolates of MTB is recommended to strengthen the identification of MDR/XDR TB and sublineages of the Beijing/W strains.

Keywords: Age Factors, Adult, Adolescent, Antitubercular Agents - therapeutic use, Child, Child, Preschool, China - epidemiology, DNA, Bacterial - genetics, Drug Resistance, Multiple, Bacterial - genetics, Extensively Drug-Resistant Tuberculosis - microbiology, Genes, Bacterial, Mycobacterium tuberculosis - genetics, Prevalence, Prospective Studies, Species Specificity, Tuberculosis, Multidrug-Resistant - microbiology, young adult

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