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eISSN: 1643-3750

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Factors Related to Long-Term Post-Stroke Cognitive Impairment in Young Adult Ischemic Stroke

Ying Huang, Shanshan Yang, Jianping Jia

(Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China (mainland))

Med Sci Monit 2015; 21:654-660

DOI: 10.12659/MSM.892554


Background: Post-stroke cognitive impairment is common and a decisive prognostic factor. However, few studies have reported on post-stroke cognition in young adults, especially long-term cognition. This study was designed to investigate the influence of baseline factors, treatments, and functional outcome on the long-term cognitive outcome in young adults with ischemic stroke.
Material and Methods: Consecutive patients aged 18–45 years between January 1, 2006 and December 31, 2010, with a first-ever ischemic stroke, were recruited for cognitive assessment by telephone from December 10 to December 31, 2013 using modified versions of “Telephone Instrument for Cognitive Status” (TICS-m) scale. The relationship of cognitive impairment with baseline factors, treatments, and functional outcome were evaluated.
Results: A total of 350 patients with an average age of 41.0±6.8 years (69.7% males and 30.3% females) were reviewed. The average follow-up period was 5.8±3.2 years, and cognitive impairment existed in 39.4% of patients at follow-up. Stroke severity on admission, functional outcome (modified Rankin Scale, mRS >2) at discharge, left anterior circulation syndrome, and stroke recurrence were markedly associated with post-stroke cognitive impairment (all P<0.01). Post-stroke cognition was also significantly related to mRS at follow-up (r=–0.563, P<0.001).

Conclusions: Post-stroke cognition was related to functional outcome: hence, treatment directed toward reducing functional disability might also reduce cognitive impairment.

Keywords: Brain Ischemia - complications, Adult, Adolescent, Cognition Disorders - etiology, Demography, Follow-Up Studies, Logistic Models, Risk Factors, Stroke - complications, Time Factors, young adult

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
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