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Jian Yin, Peng Hou, Zhiqiang Wu, Yanxiao Nie
(Department of Gastroenterology, First Affiliated to General Hospital of Chinese People’s Liberation Army, Beijing, China (mainland))
Med Sci Monit 2015; 21:118-122
DOI: 10.12659/MSM.892081
Background:
Inflammation is involved in the mechanism of inflammatory bowel disease (IBD). Omentin, a newly discovered adipokine, is thought to play an anti-inflammatory role. This study aimed to determine whether serum levels of omentin-1 are associated with the presence and disease activity of IBD.
Material and Methods:
This study consisted of 192 patients with IBD: 100 with Crohn’s disease [CD], 92 with ulcerative colitis [UC], and 104 healthy subjects. Serum levels of omentin-1 were measured using enzyme-linked immunosorbent assay (ELISA).
Results:
Serum omentin-1 levels were significantly decreased in CD and UC patients compared with healthy controls. Multivariable logistic regression analysis revealed that serum omentin-1 levels were inversely associated with the presence of CD and UC. Active CD and UC patients both had significantly decreased levels of serum omentin-1 compared with inactive CD and UC patients. In both CD and UC patients, serum omentin-1 levels were significantly associated with decreased levels of body mass index (BMI) and C-reactive protein (CRP).
Conclusions:
Decreased serum omentin-1 levels could be considered as an independent predicting marker of the presence and disease activity of IBD.