H-Index
79
Scimago Lab
powered by Scopus
JCR
Clarivate
Analytics
15%
Acceptance
Rate
call: +1.631.470.9640
Mon-Fri 10 am - 2 pm EST

Logo

Medical Science Monitor Basic Research
AmJCaseRep

Annals
ISI-Home

eISSN: 1643-3750

Get your full text copy in PDF

Effect of HLA-B-associated Transcript 3 Polymorphisms on Lung Cancer Risk: A Meta-Analysis

Junfei Zhao, Hongyuan Wang, Weizhen Hu, Yuanhong Jin

(Respiratory Department, The Sixth Affiliated Hospital of Wenzhou Medical University, People’s Hospital, Lishui, China (mainland))

Med Sci Monit 2014; 20:2461-2465

DOI: 10.12659/MSM.891141


Background: The association between the HLA-B-associated transcript 3 polymorphisms and lung cancer risk is a subject of debate. We conducted a meta-analysis to evaluate the association between these polymorphisms and lung cancer susceptibility.
Material and Methods: A systematic search of electronic databases (PubMed, EMBASE, Wanfang, and China National Knowledge Infrastructure) was performed. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated.
Results: Ten case-control studies with 37 945 and 56 807 controls were included in this meta-analysis. Overall, a significant association between rs1052486 polymorphism and lung cancer susceptibility was observed (OR=1.07, 95% CI 1.01–1.12, P=0.01). In addition, a significant association was found for rs3117582 polymorphism (OR=1.29, 95% CI 1.22–1.37, P<0.01).
Conclusions: This meta-analysis suggested that HLA-B-associated transcript 3 polymorphisms are risk factors for lung cancer.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
I agree