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eISSN: 1643-3750

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In Search of Memory Tests Equivalent for Experiments on Animals and Humans

Andrzej Brodziak, Estera Kołat, Alicja Różyk-Myrta

(Institute of Occupational Medicine and Environmental Health, Sosnowiec, Poland)

Med Sci Monit 2014; 20:2733-2739

DOI: 10.12659/MSM.891056


Abstract: Older people often exhibit memory impairments. Contemporary demographic trends cause aging of the society. In this situation, it is important to conduct clinical trials of drugs and use training methods to improve memory capacity. Development of new memory tests requires experiments on animals and then clinical trials in humans. Therefore, we decided to review the assessment methods and search for tests that evaluate analogous cognitive processes in animals and humans.
This review has enabled us to propose 2 pairs of tests of the efficiency of working memory capacity in animals and humans.
We propose a basic set of methods for complex clinical trials of drugs and training methods to improve memory, consisting of 2 pairs of tests: 1) the Novel Object Recognition Test – Sternberg Item Recognition Test and 2) the Object-Location Test – Visuospatial Memory Test. We postulate that further investigations of methods that are equivalent in animals experiments and observations performed on humans are necessary.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
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