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eISSN: 1643-3750

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Impact of oxidative/nitrosative stress and inflammation on cognitive functions in patients with recurrent depressive disorders

Monika Talarowska, Kinga Bobińska, Marlena Zajączkowska, Kuan-Pin Su, Michael Maes, Piotr Gałecki

(Department of Adult Psychiatry, Medical University of Łódź, Łódź, Poland)

Med Sci Monit 2014; 20:110-115

DOI: 10.12659/MSM.889853


Data show that up to 38.2% of the European population have a mental disorder and that recurrent depressive disorder (rDD) is among the most commonly diagnosed disabling diseases. Over the last few years, neurocognitive impairments in rDD have become a new research front focusing on the role of cognitive decline during the course of rDD and in relation to its clinical presentation and prognosis. Both immune-inflammatory and oxidative and nitrosative stress (O&NS) processes potentially play a role in development of cognitive dysfunction in rDD. New evidence shows that chronic inflammatory and O&NS reactions occur in the brains of patients with neurodegenerative disorders and those with rDD. This narrative review presents the current state of knowledge on the possible impact of selected inflammatory and O&NS enzymes on cognitive functioning in patients with rDD. We focus on manganese superoxide dismutase (MnSOD), inducible nitric oxide synthase (iNOS), and myeloperoxidase (MPO).

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
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