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Medical Science Monitor Basic Research
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eISSN: 1643-3750

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Elevated red cell distribution width and inflammation in printing workers

Ahmet Celik, Neriman Aydin, Birgul Ozcirpici, Edibe Saricicek, Hatice Sezen, Mehmet Okumus, Selim Bozkurt, Metin Kilinc

(Medical Faculty, Medical Biochemistry, Sutcu Imam University, Kahramanmaras, Turkey)

Med Sci Monit 2013; 19:1001-1005

DOI: 10.12659/MSM.889694


Background: The aim of this study was to estimate the effects of exposure to chemical compounds on systemic biochemical inflammatory markers in printing industry workers.
Material and Methods: Fifty-eight printing workers from 19 different small- and medium-sized enterprises in the printing sector were investigated. For comparison, 80 healthy workers not subjected to workplace chemicals served as control subjects.
Results: No significant differences were observed between the printing workers and control subjects with respect to age, BMI, waist circumference/hip circumference ratio, smoking, and alcohol consumption. Printing workers had significantly higher serum TNF-alpha levels (11.02±5.34 vs. 9.26±3.87 pg/ml, p=0.039), plasma fibrinogen levels (1.74±0.49 vs. 1.38±0.5 mg/dl, p=0.012), and red blood cell distribution width (RDW-SD) (49.77±3.09 vs. 47.3±2.88 p<0.01) compared to control subjects.
Conclusions: Elevation of RDW, serum TNF-alpha, and plasma fibrinogen levels in printing workers may be due to systemic toxic effects of chemical compounds used in this sector. TNF-alpha is an inflammatory cytokine that has a wide spectrum of biological activities, and fibrinogen plays an important role in pathological processes. Some compounds may be carcinogenic or mutagenic. Better designed workplaces and working conditions will help to reduce the hazardous effects of chemical compounds.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
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