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eISSN: 1643-3750

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Mirror, mirror on the wall: Hypercalcemia as a consequence of modern cosmetic treatment with liquid silicone

Jurik Schanz, Katharina Flux, Claudia Kircher, Maria Tsioga, Wolfgang Hartschuh, Peter P. Nawroth, Gottfried Rudofsky

Med Sci Monit 2012; 18(2): CS5-7

DOI: 10.12659/MSM.882450


Background:    Hypercalcemia is a common problem in clinical practice and can be related to endocrine disorders or malignant disease, especially in elderly patients. Although rare, other causes can also be responsible.
    Case Report:    Granulomatous inflammation of the skin and lymph nodes induced by intravenous or injectable silicone is a rare condition of hypercalcemia that is usually not within the scope of differential diagnosis. Here, we report a 72-year-old woman with symptomatic hypercalcemia related to cosmetic treatment of the neck. Topical applied liquid silicone by means of a focal ultrasound device induced extensive granulomatous inflammation of the skin and local lymph nodes, being the underlying cause for hypercalcemia in this case.
    Conclusions:    In rare cases, symptomatic hypercalcemia can be caused by silicone due to a severe granulomatous tissue reaction. This is the first time that a transdermal silicone treatment has been reported to cause severe granulomatous tissue inflammation.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
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