Scimago Lab
powered by Scopus
call: +1.631.470.9640
Mon-Fri 10 am - 2 pm EST


Medical Science Monitor Basic Research


eISSN: 1643-3750

Get your full text copy in PDF

Assessment of coronary artery calcification using dual-source computed tomography in adult asymptomatic patients with type 1 diabetes mellitus

Pal Maurovich-Horvat, Terez Mori, Gabor Kerecsen, Jozsef Fovenyi, Tamas Sallai, Istvan Preda, Bela Merkely, Gyorgy Jermendy

Med Sci Monit 2010; 16(7): MT59-64

ID: 880913

Background:    Experience with dual-source computed tomography (DSCT) for detecting coronary artery calcification (CAC) in patients with type 1 diabetes is limited.
    Material/Methods:    A non-contrast DSCT scan was acquired in 46 type 1 diabetic patients. All scans were suitable for evaluating CAC expressed in Agatston-scores (effective radiation dose 0.66 [0.59–0.81] mSv; median [interquartile range]).
    Results:    In 21 patients Agatston scores were ≥1 (range 1–2353), while 25 patients had no detectable calcium deposits in the coronary arteries. Patients with vs. without CAC had higher age (52 [44–59] vs. 41 [38–48] yrs; p=0.0045), longer duration of diabetes (25.3 [23.4–36.3] vs. 23.3 [15.7–30.4] yrs; p=0.0238), greater waist circumference (88 [77–98] vs. 79 [75–87] cm; p=0.0147) and BMI (26.7 [24.5–28.4] vs. 22.6 [21.7–25.6] kg/m2; p=0.0109). Moreover, patients with vs. without detectable CAC had higher serum LDL-cholesterol (3.35 [3.15–3.53] vs. 2.92 [2.62–3.33] mmol/l; p=0.0069) and serum uric acid values (236 [191–266] vs. 200 [170-219] µmol/l; p=0.0437). Hypertension was more frequent (p=0.0144) in patients with than without CAC. The 2 subgroups did not differ in long-term average HbA1c values (7.97 [7.30–8.56] vs. 8.06 [7.24–9.05]%; p=0.7491); however, estimated insulin sensitivity (estimated glucose disposal rate) was lower in patients with vs. without detectable CAC (7.43 [5.73–8.58] vs. 9.24 [8.22–10.72] mg/kg/min; p=0.0017).
    Conclusions:    Non-invasive detection of CAC is feasible with a low dose DSCT scan. CAC in type 1 diabetic patients is associated with cardiovascular risk factors rather than with long-term glycemic control.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
I agree