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Medical Science Monitor Basic Research


eISSN: 1643-3750

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Results of hepatic resection for primary hepatic angiosarcoma in adults

Yan-Ming Zhou, Bin Li, Zheng-Meng Yin, Feng Xu, Bin Wang, Wen Xu, Peng Liu, Jia-Mei Yang

Med Sci Monit 2010; 16(2): CR61-66

ID: 878352

Background: Primary hepatic angiosarcoma is an uncommon but aggressive malignancy with poor prognosis. The purpose of this study was to evaluate surgical outcomes of patients with the disease.
Material and Method: Medical records of 6 patients who underwent surgical resection for primary hepatic angiosarcoma at our institution between 1998 and 2006 were reviewed retrospectively.
Results: There were 5 men and 1 woman who ranged in age from 44 to 77 years, with a mean of 55.5 years. The most common symptoms at diagnosis were pain in the right upper quadrant, abdominal distension, weakness and weight loss. None of these patients presented with intra-abdominal hemorrhage from tumor rupture. Right hepatectomy was performed in 3 cases, extended right hepatectomy in 1 case, and left hepatectomy in the remaining 2 cases. All 6 patients had solitary masses. One patient died of perioperative complication, and another patient with microscopic tumor residuals died of disease recurrence at 6 months. Of the other 4 patients with pathological free margins, 3 died of disease recurrence at 10, 14 and 17 months, and the remaining 1 has been alive without recurrence for 29 months.
Conclusions: Although the overall outcome of surgical resection remains unsatisfactory, complete surgical resection may prolong survival of patients with solitary primary hepatic angiosarcoma without spontaneous rupture.

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