31 August 2009
High incidence of multiple primary carcinomas in HCV-infected patients with oral squamous cell carcinoma
Yumiko NagaoABCDEFG, Michio SataADEGMed Sci Monit 2009; 15(9): CR453-459 :: ID: 878175
Abstract
Background
Hepatitis C virus (HCV) infection has been associated with several extrahepatic manifestations. Oral cancer is one of them. We investigated the association among oral squamous cell carcinoma (OSCC), multiple primary cancers (MPCs), insulin resistance and HCV infection.
Material and Method
Upper gastrointestinal tract examination and determination of the presence of HCV infection were routinely done for 60 primary OSCC patients. Occurrence of MPCs was evaluated between 1992 and 2008.
Results
Of the 60 patients, 21 (35%: 15 males and 6 females; mean age 67.3+/-11.9 years) developed MPCs. Antibodies to HCV were found in 26.7% (16/60) of cases. The incidence of MPCs in HCV-infected OSCC cases was 62.5% (10/16 cases, P<0.01 vs the non-HCV-infected OSCC group); for cases without HCV infection it was 25% (11/44 cases). In HCV-infected cases, 10 MPCs with patients, hepatocellular carcinoma (HCC) was the most common outcome (5 cases), whereas gastric cancer was the most common outcome (6 cases) in non-HCV-infected 11 MPCs. In logistic regression analysis, the adjusted odds ratios on staging IV, anti-HCV positive, and over 70 years old were 15.50, 13.45, and 4.46, respectively, indicating that there were significant differences. Furthermore, the patients with HCV-infected MPCs had hyperinsulinemia.
Conclusions
HCV infection was strongly associated with the occurrence of MPCs as well as primary OSCC. HCV-infected OSCC patients in Japan should receive medical treatment to inhibit development of HCC. In patients with HCV infection, it is important to clinically examine organs other than the liver.
Keywords: Neoplasms, Multiple Primary - virology, Multivariate Analysis, Mouth Neoplasms - virology, Insulin Resistance, Hepatitis C - pathology, Hepacivirus - metabolism, Carcinoma, Squamous Cell - virology, Aged, 80 and over, Risk Factors
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
18 Mar 2024 : Clinical Research
Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative StudyMed Sci Monit In Press; DOI: 10.12659/MSM.944136
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
Most Viewed Current Articles
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952