Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 July 2008

Temporal clustering analysis: what does it tell us about the resting state of the brain?

Victoria L MorganABCDEFG, John C GoreABDEFG, Jerzy P SzaflarskiABDEFG

Med Sci Monit 2008; 14(7): CR345-352 :: ID: 863662

Abstract

Background
Several networks of synchronous blood oxygen level dependent (BOLD) oscillations have been identified in the brain during the resting state. The aim of this study was to further characterize the dynamic nature of the brain at rest by investigating the presence and distribution of coherent, transient BOLD activity in resting fMRI data using a novel method of fMRI data analysis--2dTCA.
Material and Method
High-field fMRI data were acquired in 27 subjects. The temporal clustering analysis, 2dTCA, was implemented to determine the timing of significant, spatially coherent, transient BOLD signal changes. Group maps of positive and negative coherent BOLD changes from each timing profile were created.
Results
Spontaneous increases in BOLD activity at both 3T and 4T and decreases at 4T were found in regions of the alpha rhythm circuit including the thalamus, precuneus and the occipital cortex. Additional positive and negative oscillations at 4T and a small region of positive activity at 3T were identified in the area of the brain stem reticular formation, the control center for maintaining arousal and motivation.
Conclusions
These results provide additional evidence for the presence of dynamic functional networks in the resting brain that are active while the subjects appear to be at rest and that are spatially distributed in areas responsible for maintaining consciousness and vigilance including brain stem. These findings should be considered in interpreting fMRI results which use resting baseline for comparisons.

Keywords: Oxygen - blood, Cluster Analysis, Brain Mapping, Time Factors, Rest - physiology, Brain - physiology, Algorithms

Add Comment 0 Comments

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

21 Feb 2024 : Clinical Research  

Potential Value of HSP90α in Prognosis of Triple-Negative Breast Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.943049  

22 Feb 2024 : Review article  

Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943168  

23 Feb 2024 : Clinical Research  

A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943732  

26 Feb 2024 : Clinical Research  

Predictive Value of Combined HbA1c and Neutrophil-to-Lymphocyte Ratio for Diabetic Peripheral Neuropathy in...

Med Sci Monit In Press; DOI: 10.12659/MSM.942509  

Most Viewed Current Articles

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750