Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

The concentration of galanin in postmenopausal women before and after application of hormone replacement therapy compared to women of reproductive age

Błażej Męczekalski, Radosław Słopień, Alina Warenik-Szymankiewicz

Med Sci Monit 2001; 7(5): CR928-932 :: ID: 509086

Abstract

Background: Hormone replacement therapy (HRT) during menopause exerts an essential impact on neuroendocrine regulation within the hypothalamic-pituitary system. The sex steroids, especially estrogens, are responsible for the synthesis and secretion of neuropeptides and neurotransmitters, such as galanin, neuropeptide Y, the opioid peptides, dopamine, serotonin, and others. The purpose of our research was to evaluate the concentration of galanin in postmenopausal women before and after the application of HRT, and to compare these values to the concentrations found in women of reproductive age.
Material/Methods: The experimental group consisted of 20 women (average age 53I5.2). The average time elapsed since the last menstruation in these women was 5.3 year &plusm; 1.4.
Results: The differences in the concentrations of galanin before (8.24&plusm;3.62 pg/ml) and after (5.63&plusm;2.75) the application of HRT were not statistically significant. These values were significantly lower, however (p<0.05), than the galanin concentrations in women of reproductive age (22.03&plusm;12.02 pg/ml). The concentrations of estradiol prior to the administration of HRT (0.021&plusm;0.02 ng/ml) were significantly lower (p.<0.001) than after the application of hormone replacement therapy (0.09&plusm;0.156 ng/ml). The concentrations of estradiol in the control group averaged 0.070&plusm;0.04 ng/ml, significantly higher than in the group of post-menopausal women given HRT (p.<0.05). No statistically significant difference was found between the galanin concentration in women of reproductive age and in postmenopausal women using HRT.
Conclusions: Our research results indicate that serum galanin in postmenopausal women is significantly lower than in women of reproductive age. The application of hormone replacement therapy does not restore galanin concentrations to levels typical for women of reproductive age.

Keywords: galanin, Estrogens, Menopause, menopausal symptoms

Add Comment 0 Comments

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

18 Mar 2024 : Clinical Research  

Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative Study

Med Sci Monit In Press; DOI: 10.12659/MSM.944136  

0:00

21 Feb 2024 : Clinical Research  

Potential Value of HSP90α in Prognosis of Triple-Negative Breast Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.943049  

22 Feb 2024 : Review article  

Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943168  

23 Feb 2024 : Clinical Research  

A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943732  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750