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Medical Science Monitor Basic Research


eISSN: 1643-3750

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Estimation of antithyroid antibodies occurrence in children with coeliac disease

Ewa Kowalska, Krystyna Wˆąsowska-Kr—ólikowska, Ewa Toporowska-Kowalska

Med Sci Monit 2000; 6(4): CR719-721

ID: 508186

Background:     The coexistence of coeliac disease (CD) and the diseases of autoimmune origin is often discussed in literature. In this study the evaluation of antithyroid antibodies (antimicrosomal-TMA, anti-thyreoglobulin-ATG, thyroid peroxidase antibodies anti-TPO) occurrence against clinical and laboratory determinants of thyroid function is demonstrated in children with coeliac disease.
Material/Methods:     The study was conducted on 34 IgA-EmA positive children; control group consisted of 28 children with negative screening tests for coeliac disease.
Results:     In both groups, the level of antithyroid antibodies (TMA, ATG, anti-TPO) and determinants of thyroid gland function (TSH, fT3, fT4) were evaluated; USG examination of thyroid gland was also performed. Elevated titres of antithyroid antibodies observed in children with coeliac disease (41.1%) in comparison to control group (3.56%) indicate the need for performing the screening tests for antithyroid antibodies in children with CD.

Keywords: antithyroid antibodies, coeliac disease

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