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Antioxidant defense in children with chronic viral hepatitis B and C

Agnieszka M. Chrobot, Anna Szaflarska-Szczepanik, Gerard Drewa

Med Sci Monit 2000; 6(4): CR713-718

ID: 508182

Background:     The aim of the study was estimation of antioxidant defence state in children with chronic viral hepatitis.
Material/Methods:     We examined 100 children with chronic viral hepatitis who have serological and molecular markers of HBV or HCV infection. In all patients catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities in erythrocytes were assayed.
Results:     We observed statisticaly significant decrease of CAT and SOD activities and increase of GSH - Px activity in children with chronic hepatitis B and C.
Conclusions:     Our data suggest the possibility of insufficiency of antioxidant barrier in children with chronic viral hepatitis.

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