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Agnieszka M. Chrobot, Anna Szaflarska-Szczepanik, Gerard Drewa
Med Sci Monit 2000; 6(4): CR713-718
Background: The aim of the study was estimation of antioxidant defence state in children with chronic viral hepatitis.
Material/Methods: We examined 100 children with chronic viral hepatitis who have serological and molecular markers of HBV or HCV infection. In all patients catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities in erythrocytes were assayed.
Results: We observed statisticaly significant decrease of CAT and SOD activities and increase of GSH - Px activity in children with chronic hepatitis B and C.
Conclusions: Our data suggest the possibility of insufficiency of antioxidant barrier in children with chronic viral hepatitis.