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Medical Science Monitor Basic Research
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eISSN: 1643-3750

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Evaluation of prostate specific antigen (t-PSA and f-PSA) in blood serum in screening research on prostate cancer

Aleksandra A. Kochańska-Dziurowicz, Michał Mielniczuk, Janusz Kaletka, Leonard Teneta

Med Sci Monit 1999; 5(5): CR870-873

ID: 503342


The objective of this research was to evaluate how useful the estimation of PSA (total (t-PSA) and free (f-PSA) fractions) concentration in blood serum can be in screening prostate cancer in men who were not previously examined by a urologist. TPSA and fPSA concentrations were estimated in 444 volunteers at the 38-85 age range. Men (n=76) with tPSA concentrations in 'grey zone' and above were offered further urologic examination. Sextant method prostate biopsy was performed in 45 cases. 368 volunteers (83%) had tPSA concentration within physiological range, 51 volunteers (11.5%) had tPSA concentration in 'grey zone' and 25 volunteers (5.5%) had tPSA concentration above 10 ng/ml. 7 cases of prostate cancer were found. Expected percentage of detectability of prostate cancer in the population was 2.7%.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
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