Haemorrheological changes in IgA nephropathy
Zsolt Sarszegi, Lajos Kollar, Katalin Torok, Gabor Kassai, Tibor Kovcs, Laszlo Wagner, Kalman Toth, Judit NagyMed Sci Monit 1999; 5(5): CR856-861 :: ID: 503328
Abstract
Amongst factors influencing the progression of IgA nephropathy (NP), the role of pathological haemorrheological parameters has recently aroused increasing interest. We undertook investigations in order to obtain answers whether IgA NP patients demonstrate haemorrheological changes and if so, what is their association with serum IgA and plasma fibrinogen levels, as well as whether there is any association between pathological haemorrheological parameters and clinical findings.Plasma, whole blood viscosity (p<0.001) and red blood cell (RBC) aggregation (p<0.05) were significantly
higher in patients with IgA NP (n=57), in comparison to healthy controls. We noted positive but low-level significant correlations between plasma viscosity and serum IgA (p<0.05), cholesterol (p<0.05) and triglyceride levels (p<0.01). However, we did not reveal any significant correlation between the plasma's viscosity and plasma fibrinogen. Plasma fibrinogen demonstrated a positive significant correlation with the serum creatinine level (p<0.01), proteinuria (p<0.05) and a negative correlation with the endogenous creatinine clearance (p<0.001). We noted a positive low-level correlation between whole blood viscosity and the endogenous creatinine clearance (p<0.05) and a negative one between whole blood viscosity and the serum creatinine level (p<0.05). IgA NP patients with elevated serum IgA levels (³4.2 g/l, n=23) had significantly elevated serum triglyceride levels (p<0.05), plasma viscosity (p<0.001), RBC aggregation (p<0.05) and a significantly lower endogenous creatinine clearance (p<0.05), in comparison to patients with normal serum IgA levels (<4.2 g/l, n=34). We noted no significant differences between haemorrheological parameters of subgroups with elevated (³4.0 g/l, n=30) and those with normal plasma fibrinogen levels (<4.0 g/l, n=27). Patients with elevated plasma fibrinogen levels presented with a significantly higher proteinuria (p<0.05) and a significantly lower endogenous
creatinine clearance, in comparison to patients with normal plasma fibrinogen levels. Thus, an elevated serum IgA level may have an effect on the progression of IgANP, by increasing plasma and whole blood viscosity. The elevated plasma and whole blood viscosity levels cause vasodilatation of the afferent arterioles resulting in hyperfiltration with the progression of nephropathy. High plasma fibrinogen levels result in poor prognosis, independently of its known rheological effect.
Keywords: Fibrinogen, IgA nephropathy, haemorrheology
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
26 Feb 2024 : Clinical Research
Predictive Value of Combined HbA1c and Neutrophil-to-Lymphocyte Ratio for Diabetic Peripheral Neuropathy in...Med Sci Monit In Press; DOI: 10.12659/MSM.942509
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952