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eISSN: 1643-3750

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Cyclosporin A effect of on enzymatic activity of Candida strains in vitro

Elżbieta Krajewska-Kułak, Wiaczesław Niczyporuk, Wojciech Kułak

Med Sci Monit 1998; 4(2): PI321-327

ID: 502629


Candida strains enzymatic activity was examined using API ZYM (bioMerieux). Ninety-nine Candida albicans strains and forty-seven Candida species strains were used, isolated from women with chronic Candida vulvovaginitis previously tested with many antifungal agents. Cyclosporin A (Sandoz Pharma in substantia batch 099877) was used for testing. Enzymes from the culture were compared using the API ZYM test. In the cyclosporin A group the enzymatic activity of the following enzymes of Candida albicans and Candida species was significantly decreased: (alcaline phosphatase, esterase, esterase lipase, lipase, leucine arylamidase, valine arylamidase, cystine arylamidase, naphtol-AS-BI-phosphohydrolase, alpha-glucosidase, n-aceptyl-beta-glucos-amidase, chymotrypsin, alpha-mann osidase, trypsin, alpha-fucosidase)

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
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