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Randomized clinical trial comparing the efficacy and safety of Augmentin versus cefuroxime in the treatment of chronic sinusitis in adult patients

Grzegorz Namysłowski, Maciej Misiołek, Eugeniusz Małafiej, Eugeniusz Czecior, Bogusława Orecka, Grażyna Woch, Małgorzata Mielczarek

Med Sci Monit 1998; 4(3): PI551-554

ID: 502528

The purpose of the study was to compare the efficiency and tolerance of Augmentin¨ and cefuroxime in the treatment of chronic maxillary sinusitis based on clinical and bacteriological results. A group of l15 adults with radiographically and clinically confirmed maxillary sinusitis constituted the study group. The safety of the antimicrobials was also analyzed. Patients underwent maxillary sinus aspiration twice. . Prior to the initiation of treatment sinus fluid was aspirated and sent to the laboratory. Patients were then randomized to treatment with either Augmentin¨ or cefuroxime. A second sinus puncture was performed at the end of the fourteen-day treatment. Microbiological assessment was performed again. The clinical cure rate for Augmentin¨ and cefuroxime was determined to be 98.2% and 91.1%, respectively. No significant dependence in efficacy between the two antibiotics was shown by Fisher's exact test (p=0.20). Microbiological cure was about 69%. The results indicate good efficacy for both antibiotics in the treatment of chronic sinusitis and similar very acceptable clinical tolerance

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