H-Index
79
Scimago Lab
powered by Scopus
JCR
Clarivate
Analytics
15%
Acceptance
Rate
call: +1.631.470.9640
Mon-Fri 10 am - 2 pm EST

Logo

Medical Science Monitor Basic Research
AmJCaseRep

Annals
ISI-Home

eISSN: 1643-3750

Get your full text copy in PDF

Activity of arysulfatase A in urine in children with urinary tract infection

Katarzyna Kiliś-Pstrusińska, Danuta Zwolińska, Ewa Bakońska-Pacoń, Krzysztof A. Sobiech

Med Sci Monit 1997; 3(3): CR346-349

ID: 501107


The urinary activity of arylsulfatase A (ASA), a lysosomal enzyme of proximal kidney tubules, was evaluated in children aged 6 to 16 with with a diagnosis of urinary tract infection (UTI). All patients had normal glomerular filtration rates (GFR); they were divided into 2 groups: I-with UTI only, II-with UTI and anomalies of urinary tract. Similar measurements of ASA activity were obtained for a control group of healthy children - group III. The ASA activity was compared with N-acetyl-beta-D-glucosaminidase (NAG) activity and beta-2-microglobulin (B2M) concentrations in urine - these compounds being presumed markers of damage to proximal kidney tubules. An increased ASA activity was observed in both groups of studied patients with UTI. Those found in group II children were the highest and were statistically significantly elevated above controls. There was also a positive correlation between ASA activity and NAG activity in these children. The results indicate the usefullness of measuring urinary ASA activity as a marker of proximal kidney tubule damage in children with UTI and structural anomalies of the urinary tract. There is also the implication that children with UTI and these anomalies are more susceptible to damage to the proximal tubules.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
I agree