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eISSN: 1643-3750

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Haemopexin and uptake of haem by human erythroleukemia (HEL) cells

Hana Cajthamlov‡a, Zbynek Hrkal, Dana Grebenov‡a, Ursula Muller-Eberhard, Richard J. Stockert

Med Sci Monit 1997; 3(3): BR305-312

ID: 500777


Uncomplexed haem suppresses the proliferation of human erythroleukemia (HEL) cells, the effect of which can be partially reversed by apo-haemopexin. The process of suppressed proliferation is paralleled by differentiation of the HEL cells accompanied by haemoglobin synthesis. Equivalent amounts of haem supplied to the cells in the form of haem-haemopexin neither affected their proliferation nor promoted haemoglobin synthesis. Haemopexin internalization by HEL cells only occurred if the haem-haemopexin complexes were continuously supplied to the cells at 37 °C. It suggests that fluid flow endocytosis rather than receptor mediated endocytosis is operative in this process.

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