Get your full text copy in PDF
Hana Cajthamlova, Zbynek Hrkal, Dana Grebenova, Ursula Muller-Eberhard, Richard J. Stockert
Med Sci Monit 1997; 3(3): BR305-312
Uncomplexed haem suppresses the proliferation of human erythroleukemia (HEL) cells, the effect of which can be partially reversed by apo-haemopexin. The process of suppressed proliferation is paralleled by differentiation of the HEL cells accompanied by haemoglobin synthesis. Equivalent amounts of haem supplied to the cells in the form of haem-haemopexin neither affected their proliferation nor promoted haemoglobin synthesis. Haemopexin internalization by HEL cells only occurred if the haem-haemopexin complexes were continuously supplied to the cells at 37 °C. It suggests that fluid flow endocytosis rather than receptor mediated endocytosis is operative in this process.