Scimago Lab
powered by Scopus
call: +1.631.470.9640
Mon-Fri 10 am - 2 pm EST


eISSN: 1643-3750

Get your full text copy in PDF

Risks and benefits of open-lung biopsy in the mechanically ventilated critically ill population: A cohort study and literature review

Yaseen Arabi, Raees Ahmed, Qanta Ahmed, Masood Ur Rahman, Nizar Yamani

Med Sci Monit 2007; 13(8): CR365-371

ID: 491653

Background:    The study’s objective was to determine the diagnostic yield, morbidity, mortality, and therapeutic impact of open-lung biopsy (OLB) in mechanically ventilated, critically ill patients.
    Material/Methods:    The study was conducted as a retrospective cohort study in multidisciplinary ICU in a tertiary level academic center and included all patients with respiratory failure and diffuse pulmonary infiltrates who underwent OLB between 1996-2004. Patient demographics, presenting symptoms, co-morbidities, APACHEII and SAPS II scores, and the diagnostic work-up preceding OLB were recorded. Pre- and post-biopsy PaO[sub]2[/sub]/FiO[sub]2[/sub] ratios, lung compliance, and PEEP were documented. The impact of histological diagnosis on the management was determined. Operative complications including bleeding, intraoperative hemodynamic instability, and persistent air leak were also reviewed.
    Results:    Fourteen patients were identified. The median ventilator time before OLB was 8.5 days. Nine patients were on inotropes and seven on renal replacement therapy at the time of biopsy. PaO[sub]2[/sub]/FiO[sub]2[/sub] ratio, lung compliance, and PEEP levels pre- and post-biopsy were not significantly different. Histological diagnoses were established in all 14 patients. Biopsy results led to the addition of a new therapy in 9 patients (64%) and the withdrawal of unnecessary therapy in 2 patients (14%). No major perioperative or intraoperative complications occurred. Six (43%) patients were discharged alive from the hospital.
    Conclusions:    Open-lung biopsy in mechanically ventilated critically ill patients provides significant diagnostic information leading to change in the management of the majority of patients. The procedure is well tolerated and associated with an acceptable benefit-to-risk ratio.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
I agree