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Medical Science Monitor Basic Research
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eISSN: 1643-3750

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Elevated circulating transforming growth factor β-1 may explain poorer renal survival in type II diabetics with chronic hepatitis C

Michael C. Peterson

Med Sci Monit 2007; 13(5): RA81-85

ID: 484619


Hepatitis C is reported to be associated with poorer renal survival in patients with diabetes. The mechanism for this observation has not been elucidated. Transforming growth factor β-1 is involved in signaling for human disease involving fi brosis and excess matrix deposition including diabetic nephropathy. Hepatitis C virus core protein is known to upregulate transcription of TGF β-1 in the liver and HCV patients have elevated levels of circulating TGF β-1 versus controls. There is evidence that elevated circulating TGF β-1 levels result in more rapid progression of nephropathy and that lowering circulating TGF β-1 levels with an angiotensin converting enzyme inhibitor correlates with treatment effi cacy in diabetic nephropathy. This paper outlines a hypothesis that the elevated level of circulating TGF β-1 which is associated with HCV is a mediator of more rapid progression of diabetic renal disease in persons with HCV.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
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